Ensuring Data Continuity and Windows 11 Compatibility for Legacy Laboratory Systems with Chromperfect ProteinSimple iCE3

For many years, Chromperfect has been one of the supported data-system options used with the ProteinSimple iCE3. The software provides precise, compliant analysis and reporting tools for imaged capillary isoelectric focusing (icIEF) workflows. Many laboratories chose Chromperfect because it offered stable processing of iCE3 CDF data and a familiar, chromatography-style interface.

Now that the iCE3 platform has been discontinued, many laboratories are looking for guidance on maintaining continuity and ensuring compatibility with modern Windows 11 systems. Chromperfect continues to provide that support.

Understanding the iCE3 Workflow

The iCE3 performs imaged capillary electrophoresis, separating proteins according to their isoelectric point (pI). Each run produces a CDF data file, which Chromperfect reads and processes directly.

A dedicated processing mode—ElectroCdfMode—recognizes the reference markers and automatically plots peaks on a calibrated pI axis. This gives users a clean, chromatogram-style representation of charge variants with automatic pI alignment.

This long-standing compatibility has made Chromperfect a reliable choice for laboratories working with iCE3 data.

Upgrading to Chromperfect 10 for Windows 11

Most historical iCE3 systems shipped with Chromperfect versions built for Windows 7 or 10. As operating systems progress, these older versions may no longer operate reliably or meet modern security expectations.

Chromperfect 10 provides:

• Full Windows 11 compatibility

• Faster performance and improved data security

• Support for iCE3 CDF data imports

• 21 CFR Part 11 compliance with user logins, audit trails, and access controls

• Seamless migration—no changes to existing icIEF workflows

Upgrading ensures validated methods and archived results remain accessible, traceable, and compliant.

Why Continuity Matters

When hardware reaches end-of-life, preserving historical data becomes essential. Laboratories operating under GxP or ISO 13485 cannot lose traceability or be forced into unnecessary re-validation.

Chromperfect safeguards legacy datasets and enables operating-system upgrades without disrupting workflows or analytical environments.

Technical Support and Resources

Chromperfect continues to support laboratories worldwide that still operate the legacy iCE3 platform. Whether upgrading a standalone workstation or a validated multi-user environment, our team can assist with planning, migration, and remote installation.

For technical documentation and upgrade inquiries, visit chromperfect.com.For details on current ProteinSimple platforms, visit proteinsimple.com.

The Importance of Data Integrity

Reliable analytical data must be complete, accurate, and fully traceable. Chromperfect maintains data integrity throughout system upgrades, ensuring that historical results remain verifiable and compliant with regulatory expectations.

Future-Proofing Your Laboratory

Upgrading to Chromperfect 10 ensures compatibility with Windows 11 and positions your laboratory to adopt future improvements. Chromperfect continues to evolve, providing long-term stability and compatibility for icIEF workflows.

Key Takeaway

Chromperfect has supported iCE3 laboratories for many years by providing stable, compliant processing of icIEF CDF data. Although instruments change, data continuity remains essential—and Chromperfect 10 ensures your iCE3 workflows remain secure, compatible, and future-ready.