If a chromatography peak suddenly develops a flat top, detector overload is an obvious suspect — but it is not the only possible cause. A flat top chromatography peak can originate in the detector itself, in the analog data acquisition hardware, or, in one specific historical case, within the chromatography data system. Correctly identifying where the signal is being limited matters because each cause requires a different solution. Diluting a sample will not correct an acqui

Clear explanation of the difference between ICF XML configuration files and MIC setpoint files in Chromperfect, including setup vs operational roles and how each file type functions within an ICF-controlled instrument.